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KMID : 0382619880080020863
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Hanyang Journal of Medicine
1988 Volume.8 No. 2 p.863 ~ p.873
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Effects of the Adrenergic Blocking Agents, Phentolamine and Propranolol, on the Blood Concentrations of Glucose and Insulin in the Rats
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Abstract
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To investigate the effects of the adrenergic blocking agents, phentolamine and pro-pranolol on the glucose metabolism the blood concetrations of glucose and insulin in-duced by glucose 500mg, isoproterenol 180ug, tolbutamide 2mg, phentolamine 5mg, tolazoline 5mg and propranolol 5mg per kg of body weight with or without the adrenergic blocker pretreatment were determined and compared each other. 1) Blood glucose levels were significantly increased to 1.8 and 1.5 times of the basalby isoproternol and glucose respectively while decreased to 0.6 times of the basal by tolbutamide and not significantly changed by the adrenergic blocking agents, phentolamine, tolazoline and propranolol. Serum. immunoreactive insulin levels were increased to 6.3, 3.7, 3.7, 2.5 and 2.2 times of the basal bisoproterenol, glucose, tolbutamide, tolazoline and phentolamine while decreased to 0.7 timesof the basal by propranolol 2) In the groups of phentolamine pretreatment the blood glucose levels were decreased
in 2% of those in without pretreatment by glucose, while increased in 18 and 15%
by isoproterenol and tolbutamide respectively. Serum immunoreactive insulin levels
were increased in 26, 25 and 13% by tolazoline, glucose and isoproterenol respec-
tively, increased rates, however, were lower than those of phentolamine itself.
3) In the groups of propranolol pretreatment the blood glucose levels were significantly
decreased in 46 and 37% of those in without pretreatment by glucose and isoproterenol respectively while significantly increased to 1.3 times by tolazoline and not significantly changed by phentolamine or tolazoline Serum immunoreactive insulin levels were decreased with propranolol pretreat-ment in 69, 60, 45, 45 and 23% of those in without pretreatment by glucose, tolbutamide, phentolamine, tolazoline and isoproterenol respectively. It seems reasonable to conclude from these results that fladrenoceptors acts preferentially on glucose metabolism.
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KEYWORD
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